Acute generalized exanthematous pustulosis - Akutna Generalizirana Eksantematozna Pustuloza
Akutna Generalizirana Eksantematozna Pustuloza (Acute generalized exanthematous pustulosis) (AGEP) je redka kožna reakcija, ki je v 90 % primerov povezana z dajanjem zdravil. Za akutna generalizirana eksantematozna pustuloza (acute generalized exanthematous pustulosis) so značilni nenadni kožni izbruhi, ki se v povprečju pojavijo pet dni po začetku jemanja zdravila. Ti izpuščaji so pustule, tj. majhne rdeče bele ali rdeče izbruhe na koži, ki vsebujejo moten ali gnojen material (gnoj). Kožne lezije običajno izginejo v 1–3 dneh po prekinitvi jemanja zdravila, ki povzroča motnje.
☆ V rezultatih raziskave Stiftung Warentest iz Nemčije leta 2022 je bilo zadovoljstvo potrošnikov z ModelDermom le nekoliko nižje kot s plačanimi telemedicinskimi svetovanji.
Razširjene lezije z eritemom in pustulami se pojavijo nenadoma.
References
Acute generalized exanthematous pustulosis (AGEP) je kožna reakcija, ki jo zaznamujejo majhne, z gnojem napolnjene izbokline na rdeči podlagi kože. Običajno se zgodi, ko nekdo vzame določena zdravila, kot so antibiotiki, in se hitro razširi po telesu. Po prenehanju jemanja sprožilnega zdravila simptomi običajno izginejo v dveh tednih, pogosto pustijo nekaj luščenja kože. Čeprav običajno niso resni in so omejeni na kožo, je hude primere mogoče razvrstiti skupaj z drugimi resnimi kožnimi reakcijami, kot sta Stevens-Johnson syndrome ali toxic epidermal necrolysis. Zdravljenje je predvsem podporno zdravljenje in napoved za popolno ozdravitev bolezni je običajno odlična.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
76-letni moški je prišel na urgenco, ker se mu je v zadnjih dveh dneh spremenila koža. Zdravniki so na njegovem trupu, rokah in nogah našli rdeče lise in dvignjena področja. Sčasoma so se te lise združile in na rdečih območjih so se pojavile mozoljem podobne izbokline. Testi so pokazali visoko število belih krvnih celic z veliko vrste, imenovane nevtrofilci, in povečano raven C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
